BOLD imaging of compressed breast hemodynamics
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چکیده
ABSTRACT Time-resolved hemodynamic changes in the breast resulting from the application of external compression have recently been investigated as potential biomarkers of breast cancer [1]. Using high time-resolution near-infrared diffuse optical spectroscopy to monitor postcompression hemodynamics, our group was able to demonstrate the non-invasive estimation of breast tissue blood flow and oxygen consumption [2,3]. Encouraged by these results, we have designed an integrated MRI-optical breast compression platform that will enable simultaneous acquisition of MR and optical images. MR scans can provide structural information to enhance the optical reconstructions, as well as dynamic blood oxygen level dependent (BOLD) images sensitive to deoxy-hemoglobin (HbR) concentration for cross-validation against optically measured HbR values. In this submission we describe the MRI breast compression platform and initial results from dynamic MRI scans of the compressed breast, indicating contrast between the BOLD signal time-course in fibro-glandular vs. adipose tissue.
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تاریخ انتشار 2009